GitHub Advisoryadvisory · PyPI
GHSA-8qxc-57hf-hc9j Open Babel has uninitialized pointer dereference in PQS pFormat
HIGH
Official page ↗
- Aliases
- CVE-2022-46280
- Ecosystem
- PyPI
- Packages
- openbabel
- Severity
- High
- CVSS vector
- CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H
- Weaknesses
- CWE-824
- Reviewed
- 2026-07-01
Affected packages
• PyPI openbabel: < 3.2.0 → fixed in 3.2.0
Description
Summary
A memory-safety vulnerability in Open Babel's PQS parser caused an
uninitialized pointer dereference when reading a crafted input file.
Details
The flaw was in the `pFormat` handling of the PQS reader. A malformed
input caused the parser to dereference a format pointer that had
never been initialized.
Impact
Open Babel is a C++ library and CLI used to read and write chemistry
file formats; it is shipped by Linux distributions and embedded in
services that may parse untrusted input. Triggering this vulnerability
requires the victim to open a malicious PQS file with the `obabel`
tool, the `OBConversion` API, or any of the language bindings (Python,
Ruby, Java, R, Perl, C#, PHP).
Affected versions
All releases up to and including 3.1.1.
Patched version
3.2.0 (released 2026-05-26).
Patch
Fix commit: https://github.com/openbabel/openbabel/commit/2a7d2cda
A minimized reproducer for this CVE is checked in under
`test/files/fuzz_regress/` and is exercised on every CI build under
ASAN+UBSAN by the `fuzzregresstest` harness.
Credit
Reported by Cisco TALOS.
Related
Alias · CVE (1)
- CVE-2022-46280 A use of uninitialized pointer vulnerability exists in the PQS format pFormat functionality of Open Babel 3.1.1 and master commit 530dbfa3. vulnerability
Weakness · CWE (1)
- CWE-824 Access of Uninitialized Pointer weakness
References
- https://github.com/openbabel/openbabel/security/advisories/GHSA-8qxc-57hf-hc9j web
- https://nvd.nist.gov/vuln/detail/CVE-2022-46280 advisory
- https://github.com/openbabel/openbabel/commit/2a7d2cda8bd47daade2e555e34b69651a2e132ef web
- https://github.com/openbabel/openbabel package
- https://talosintelligence.com/vulnerability_reports/TALOS-2022-1670 web
- https://www.talosintelligence.com/vulnerability_reports/TALOS-2022-1670 web